منابع مشابه
The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.
BACKGROUND Acute coagulopathy of trauma (ACOT) has been described as a very early hypocoagulable state, but the mechanism remains controversial. One proposed mechanism is tissue hypoperfusion leading to protein C activation, with subsequent inhibition of Factors V and VIII. Variability in trauma has impeded the use of clinical data towards the elucidation of the mechanisms of ACOT, but thrombel...
متن کاملClot retraction facilitates clot lysis.
Platelet facilitation of clot lysis was studied using the dilute clot lysis assay, a standardized assay for fibrinolysis shown to correlate with the development of postoperative deep vein thrombosis. Clots prepared from dilute platelet poor plasma showed prolonged clot lysis when compared with clots prepared in a similar fashion from dilute platelet rich plasma. Since in the presence of platele...
متن کاملProcoagulant activity on platelets adhered to collagen or plasma clot.
In a new 2-stage assay of platelet procoagulant activity (PCA), we first subjected gel-filtered platelets to adhesion on collagen (as a model of primary hemostasis) or plasma clots (as a model of preformed thrombus) for 30 minutes, and then the adherent platelets were supplemented with pooled, reptilase-treated, diluted plasma. Defibrinated plasma provided coagulation factors for assembly on pl...
متن کاملSize matters for polyP to clot.
Size matters for polyP to clot ---------------------------------------------------------------------------------------------------------------Usha R. Pendurthi THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT TYLER All living organisms contain polyphosphate—a linear polymer of inorganic phosphate. Depending on where they are derived, the polymers exist in different lengths. In this issue of Blo...
متن کاملContribution of Fibrin Stabilization to Clot Strength
A B S T R A C T The contribution of fibrin stabilization to clot strength, measured as the static elastic modulus, was evaluated in human plasma by two independent procedures. In the first approach, amine inhibitors of fibrin stabilization were examined for their effects on the rigidity of normal plasma clots. It is a unique property of these inhibitors that they do not interfere with the rever...
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ژورنال
عنوان ژورنال: Chest
سال: 2019
ISSN: 0012-3692
DOI: 10.1016/j.chest.2019.08.1281